However, certain isolated conditions like idiopathic thrombocytopenic purpura (ITP), thrombotic thrombocytopenic purpura (TTP), and disseminated intravascular coagulation (DIC) have a similar presentation to these complications, hence making the treatment challenging in Hb S/β patients. Here, GSTM1 is linked to thrombotic thrombocytopenic purpura.