In COVID-19 patients with ARDS, hyperinflammation occurred due to the proinflammation cytokine release in high numbers and also due to the secretion of chemokine in large numbers (CCL2, CCL3, CCL5, CXCL8, CXCL9, and CXCL10, among others) [40]. This evidence concerns the gene CXCL8 and COVID-19.