Interestingly, dysregulation of eight of those genes in this cohort complies with the fact that CAT and OGG1 are downregulated and CASP3, COMT, CYP1B1, DPYD, NQO1, and PTGS1 are upregulated in DKD, suggesting that the target compounds are clearly interacting with potential genes associated with diabetic nephropathy [58]. This evidence concerns the gene COMT and diabetic kidney disease.