EGFR and lung carcinoma: Because EGFR inhibition induces the reactivation of mitochondrial OXPHOS in NSCLC cells [9], and the lung cancer cells with acquired EGFR-TKI resistance exhibited decreased EGFR kinase signaling activities (Figure 1(d)), OXPHOS activities in the three lung cancer cell lines with acquired EGFR-TKI resistance were compared with those in their parental cell lines.