EDN1 and cancer: Shifted ET-1 homeostasis may influence and predict development and progression of suboptimal health conditions, metabolic impairments with cascading complications, ageing and related pathologies, CVD, neurodegenerative pathologies and aggressive subtypes of cancer, such as metastasing breast and prostate malignancies, thereby modulating individual outcomes of both non-communicable and infectious diseases such as COVID-19 with versus without severe complications.