EDN1 and hypertensive disorder: A study which examined the effect of combined resistance and aerobic exercise (CRAE) training in obese pre-hypertensive girls on BP, body composition, blood nitrite/nitrate (circulating NO marker) and ET-1 levels [1] has demonstrated that CRAE training managed to reduce SBP, arterial stiffness, increased total nitrite/nitrate and decreased ET-1 levels and decreased percentage of body fat and increased lean body mass in obese adolescent girls with pre-hypertension.