Moreover, Noor et al. recently evaluated the immunomodulatory and anti-cytokine therapeutic potential of curcumin and its derivatives targeted against COVID-19 immunological human host receptors, i.e., ACE2, IL-1β, IL-6, TNF-α, and protease-activated receptor (PAR)-1 to prevent viral infection and control overproduction of early clinical responses. This evidence concerns the gene TNF and COVID-19.