In 2015, the ACRG provided a new gastric cancer molecular classification, which also identified four molecular subtypes: MSI subtype, microsatellite stable with epithelial to mesenchymal transition features (MSS/EMT), MSS/TP53 mutant (MSS/TP53+), and MSS/TP53 wild-type (MSS/TP53-) [6]. This evidence concerns the gene TP53 and gastric cancer.