As a protein that plays a key role in phosphate regulation, FGF23 is involved in controlling the metabolism of phosphate, parathyroid hormone, and 1,25 dihydroxy vitamin D. FGF23 can not only regulate phosphate homeostasis but also further promote disease progression, left ventricular hypertrophy, and increase the occurrence and death of CVD [1]. Here, FGF23 is linked to left ventricular hypertrophy.