ESR1 and breast neoplasm: The nonsignificant increase in serum levels of estradiol observed at the dose of 100 mg/kg indicates the ability of D. edulis to act in a tissue-specific way and to antagonize estrogen receptors in the mammary glands and breast tumors, thus reducing estradiol levels in these tissues, since estradiol is known to stimulate its biosynthesis in estrogen-sensitive tissues [50].