The anticancer effect of this extract would be mediated by the increase of ROS production (indicated by elevated levels of MDA), responsible for cell damage [41, 55] and the inhibition of Akt pathway (indicated by elevated levels of antioxidant enzymes), an oncogene protein, where the activation stimulated by ROS is known to inhibit the production of antioxidant enzymes and cell apoptosis, promoting tumor cell survival [53, 54]. The gene discussed is AKT1; the disease is neoplasm.