NFKB1 and liver dysplastic nodule: The events in diabetes, such as hyperglycemia and advanced glycation end products (AGEs), upregulate the expression of NFκB (the proinflammatory transcription factor), resulting in the infiltration of inflammatory cells in the diabetic kidney, which secrete proinflammatory cytokines and ROS, facilitating the development of fibrosis in DN [8, 9].