Moreover, hsa_circ_0028861 also exhibited good diagnostic performance with an AUC of 0.78 in discriminating AFP (−) HCC patients from the combination of chronic HBV and cirrhosis patients, and the corresponding sensitivity and specificity was 71.43 and 80.77%, respectively (Figures 4C,F and Table 4). This evidence concerns the gene AFP and hepatocellular carcinoma.