NLRP3 rs10754558 polymorphism contributes to significantly reduce the risk of AIDs in the allelic model [G vs. C: 0.78 (0.71-0.87)], homozygote co-dominant model [GG vs. CC: 0.63 (0.51-0.77)], heterozygote co-dominant model [GC vs. CC: 0.78 (0.66-0.91)], dominant model [GG/GC vs. CC: 0.73 (0.63-0.84)], and recessive model [GG vs. GC/CC: 0.73 (0.62-0.88)]. The gene discussed is NLRP3; the disease is AIDS.