In the Han group, the haplotypes of the SLC22A3 C-A and SYTL3–SLC22A3 A-C-A-A-C-A and G-T-C-A-C-A had a protective effect, while the haplotype of SYTL3–SLC22A3 A-C-A-A-A-G increased HLP-related morbidity. The gene discussed is SYTL3; the disease is hyperkeratosis lenticularis perstans.