PDE4D and psychiatric disorder: Pten (Chr 19 male Hypothermia QTG), Rps6kb1/p70S6K (Chr 11 Mobility and male Hypothermia QTG), and Pde4d (Chr 13 female Hypothermia QTG) were the most well connected QTGs in terms of associations with drugs of abuse and psychiatric disease (Supplementary Figure 3).