BRCA2 and cancer: Finally, among rare variants from the mother, as cancer driver genes, a missense mutant ALK (chr2: 30143039G > T, V163L, rs55697431), and a stop-gain mutant BRCA2 (chr13: 32911104C > A, S871Ter, rs397507634) were focused through screening using the IntOGen database (Figure 2A).