Despite significantly upregulated levels of inflammatory molecules in the plasma of COVID-19 patients and transiently induced expression of ISGs in peripheral immune cells, an impaired cytokine response in blood myeloid cells and pDCs, with markedly reduced expression of IL-6, TNF and IL-1β upon TLR stimulation, was observed emphasizing a tissue origin of the plasma cytokines (108). This evidence concerns the gene TNF and COVID-19.