As shown in Figures 2E, F, IFN-γ and IL-17A levels were significantly higher in active AOSD patients compared with HC (both p<0.01) or non-severe COVID-19 patients (both p<0.001), but there was no significant difference in IFN-γ or IL-17A levels between COVID-19 patients and HC. This evidence concerns the gene IFNG and COVID-19.