IL18 and COVID-19: The ROC analysis of the putative biomarkers revealed that IL-18 levels at the cut-off value 190.5pg/mL had the highest discriminative power with AUC of 0.948, the sensitivity of 91.3%, specificity of 95.8%, and an accuracy of 91.5% for differentiating active AOSD from severe COVID-19 (Figure 3B).