Gal-3 and Gal-9 have recently been found to play crucial roles in the pathogenesis of COVID-19 (27, 28) and AOSD (30, 33), and our study is the first to reveal higher Gal-3, Gal-9, and sTIM-3 levels in active AOSD compared with COVID-19 patients. The gene discussed is LGALS9; the disease is COVID-19.