Distinct from the previously published studies that have identified (enrichment of) rare TLR7 variants in severe COVID-19 who were 1) males <35 years of age without comorbidities (13), 2) males <60 years of age with or without comorbidities (14) or 3) a group of unselected patients (19), in this study we have selected males <50 years of age without comorbidities predisposing to severe COVID-19. The gene discussed is TLR7; the disease is COVID-19.