A limitation of this work is that we mainly focused on the anti-inflammatory effect of Rux rather than its other roles, such as its angiogenic effect after IS through which it rescues cerebral ischemia injury; this could be investigated by measuring the expression of other cytokines downstream of JAK2/STAT3, G-CFS cytokines, growth factors and VEGF (46). The gene discussed is VEGFA; the disease is brain ischemia.