In this regard, taking advantage of pre-existing anti-tumor antigen specificity, tumor-specific T-cells clones were reprogrammed to iPSCs to produce rejuvenated and functionally competent T-cells recognizing common tumor-specific antigens including MART-1 (melanoma), WT1 (leukemia) or GPC3 (hepatic and ovarian carcinoma) (159, 163). Here, GPC3 is linked to ovarian carcinoma.