Interestingly, expression of class I and class II molecules in tumor cells can be, at least to a certain extent, induced by radiotherapy, several chemotherapeutic agents, a range of small compounds including histone deacetylase (HDAC) inhibitors, tyrosine kinase inhibitors (203), CDK4/6 inhibitors (204), or IFN-γ (205). This evidence concerns the gene IFNG and neoplasm.