In Kaplan-Meier analysis participants with depression at baseline, HSV-2 coinfection at baseline, set point HIV VL ≥5 log10 copies/mL (vs. < 5), and persistence of symptoms ≥ 2 weeks (vs. < 2 weeks) reached the endpoint of a CD4+ T cell count < 350/μL at a significantly faster rate (Figure 4). This evidence concerns the gene CD4 and major depressive disorder.