In the RP group there were greater proportions of patients aged > 30 years, monthly incomes < $350 US, HSV-2 coinfection, depression, duration of acute symptoms ≥ 2 weeks, duration of acute symptoms ≥ 3 weeks, and symptoms of acute malaise, and baseline HIV VL, annual CD4+ T cell count reduction speed post-seroconversion, set point VL were higher. The gene discussed is CD4; the disease is major depressive disorder.