For instance, MHC class I-related chain molecules A and B (MICA and MICB) and natural cytotoxicity triggering receptor 3 ligand 1 (NR3LG1), also referred to B7-H6, are widely expressed by tumor cells (50, 51), and they have been reported to be substrates of ADAM17 (52–55). This evidence concerns the gene ADAM17 and neoplasm.