In contrast to anti-cryptococcal IgG levels, anti-cryptococcal CPS and protein IgM titers were unaffected by progression of the infection (Figures 2C, E), with exception of elevated anti-Cn IgM levels in WT and IL-4Rα-/- mice on day 42 post infection (Supplementary Figure 2D). This evidence concerns the gene CD40LG and infection.