CD40LG and cutaneous mastocytosis: In this study, we characterized the humoral immune response in HIV-positive and HIV-negative CM patients as well as healthy individuals regarding (i) the quantity of anti-cryptococcal IgG and IgM antibodies to identify the dominant isotype in anti-cryptococcal humoral immunity, and (ii) the target proteins of the human humoral immune response against C. neoformans to identify disease-associated cryptococcal proteins.