IL4R and cryptococcosis: Therefore, we used wild type (WT) Balb/c mice which are susceptible to disseminated cryptococcal infection, and IL-4Rα-deficient (IL-4Rα-/-) Balb/c mice which do not succumb to cryptococcal infection, but develop a latent pulmonary infection (75), after intranasal infection with the C. neoformans serotype D strain 1841.