In COPD the burden of inflammation rarely meets that seen in pneumonia or ARDS, however it was recently shown that neutrophils isolated from COPD patients, when incubated with simvastatin, improved their migratory dynamics towards CXCL8 and fMLP, to levels similar to aged matched healthy controls (143), indicating a potential benefit of statins directly on leukocyte migration. This evidence concerns the gene CXCL8 and chronic obstructive pulmonary disease.