Recently, in a phase I study anti-TIGIT antibody vibostolimab was demonstrated to be well tolerated as monotherapy and in combination with pembrolizumab (anti-PD-1 antibody), achieving antitumor activity in patients with advanced NSCLC naïve or refractory to anti-PD-1/PD-L1 therapy (NCT02964013) (103, 104). This evidence concerns the gene PDCD1 and non-small cell lung carcinoma.