TIGIT is expressed on human tumor-infiltrating CD8+ T cells, NK cells, Th and Treg cells in melanoma (54, 55), NSCLC (56, 57), colon cancer (52), HCC (31, 58), gastric cancer (59), glioblastoma (60) and hematological malignancies (42, 61, 62). Here, TIGIT is linked to hepatocellular carcinoma.