CD4 and allergic rhinitis: Of interest, at the experimental level oral administration of BALB/C to mice sensitized by ovalbumin with the tricyclic-antidepressant desipramine diminished symptoms of allergic rhinitis symptoms in mice, up regulated CD4+CD25+Foxp3+ Treg cells and reduced CD4+IL-17+ Th17 cells, which were significantly increased in mice not receiving this antidepressant.