Notwithstanding these limitations, our findings demonstrate that the IRF7lo immunophenotype markedly increases risk for severe airways inflammation to virus/allergen coexposure, and moreover demonstrate that pretreatment with OM-85 has potential to mitigate susceptibility to ensuing airways inflammation by upregulation of T1-associated pathways (Il12rb1, Cxcl9) and attenuation of T2 inflammation. Here, CXCL9 is linked to inflammatory response.