Failure to orchestrate a rapid immune response via IRF7 following viral infection in a T2hi biased system may also contribute to exacerbated airways inflammation and remodeling, given the inverse relationship between IRF7 and IL-33 expression (key driver of type 2 inflammation) observed in human airway cells in vitro (40) and ex vivo (4), and in animal models (41). This evidence concerns the gene IL33 and viral infectious disease.