IRF7 and asthma: In the present study we have extended these investigations to encompass comprehensive systems-level analyses of underlying gene coexpression networks in lung and bone marrow tissues, and sought firstly to elucidate the molecular basis for these apparent differences in IRF7-related response profiles following virus/allergen co-exposure in PVG versus BN rats, and secondly to test the hypothesis that the asthma risk-associated IRF7lo immunophenotype can be reprogrammed via pretreatment with the immune training agent OM-85 to increase resistance to virus/aeroallergen challenge.