In oesophageal cancer, NY-ESO-1, MAGE-A, TTK and LAGE-1 are highly expressed and induce specific cytotoxic T lymphocytes (CTLs) to exert specific killing effects on tumour cells, and it was demonstrated by several clinical trials that immunotherapies are effective for oesophageal cancer (63). This evidence concerns the gene TTK and carcinoma of esophagus.