CD274 and neoplasm: For example: Demonstrated in mouse breast, pancreatic and glioblastoma tumour models that anti-PDL1, anti-VEGFR2, and anti-LTβ receptor (LTβR) therapies were showed to induce high endothelial venules (HEVs) and to enhance cytolytic of TME, which leading to the destruction of tumours and transforming immune-cold glioblastomas into immune-rich ones (129).