A study of 264 high-grade serous ovarian cancer (HGSC) patients from two cohorts and 340 HGSC cases from The Cancer Genome Atlas showed that CXCL13 plays a key role in shaping anti-TME by promoting the maintenance of CXCR5+CD8+ T cells in TLSs which supporting the idea that combination of CXCL13 and PD-1 in HGSC clinical study (163). Here, CXCL13 is linked to ovarian serous adenocarcinoma.