Cluster analysis was applied to identify SLE patients with similar autoantibody patterns and verify that the cluster of patients with anti-dsDNA/LAC/anticardiolipin (aCL) antibody was more closely related to arterial and/or venous thrombotic events and thrombocytopaenia, whereas it cannot test the causal association between cerebrovascular accidents and SLE (22, 23). The gene discussed is ACLY; the disease is systemic lupus erythematosus.