Interestingly, the secretion of IL-6, IL-8, TNF-α, IFN-γ and IL-10 was significantly elevated in CARγ and CARζ cells treated with SARS-CoV-2 virions, suggesting that these CAR macrophages may not be suitable for application in severe patients or patients with late-stage COVID-19. This evidence concerns the gene IFNG and COVID-19.