To further explore the effect of BLM on the expression of candidate Yaa locus genes (TLR7, TLR8, Arhgap6, Msl3, and Tceanc) associated with autoimmunity, quantitative real-time PCR (RT-qPCR) was performed to compare the mRNA expression of these genes in the lung tissues of both BLM and PBS groups in Yaa and BXSB mice. This evidence concerns the gene TLR8 and Autoimmunity.