In the ICI-treated COAD cohort (Figure 2A), the genes with the top 20 mutation frequencies were APC, KRAS, TP53, PIK3CA, KMT2D, ARID1A, PTPRS, RNF43, KMT2C, TCF7L2, ZFHX3, FAT1, NCOR1, SMARCA4, NF1, PTCH1, SMAD4, ARID1B, BRCA2 and CREBBP. Here, NF1 is linked to colon adenocarcinoma.