In the ICI-treated COAD cohort (Figure 2A), the genes with the top 20 mutation frequencies were APC, KRAS, TP53, PIK3CA, KMT2D, ARID1A, PTPRS, RNF43, KMT2C, TCF7L2, ZFHX3, FAT1, NCOR1, SMARCA4, NF1, PTCH1, SMAD4, ARID1B, BRCA2 and CREBBP. The gene discussed is KMT2C; the disease is colon adenocarcinoma.