Moreover, compared to the previously generated Spike-protein-targeting CR3022-CAR-NK cells (24), S309-CAR-NK cells show superior killing activities against target cells [e.g., A549, an epithelial carcinoma derived from a 58 year old Caucasian male with a non-small cell lung carcinoma (25)] expressing SARS-CoV-2 S protein and mutant S protein (hereinafter, A549-Spike and A549-Spike D614G, respectively) in vitro. Here, CHMP5 is linked to non-small cell lung carcinoma.