Similarly, other tumor-specific promoters have also been adopted including the E2F-1 promoter (Hemminki et al., 2015), p53 promoter (Wang et al., 2008), cyclo-oxygenase 2 (cox2) promoter (Bauerschmitz et al., 2006), and the α-fetoprotein (AFP) promoter (Kim et al., 2002). Here, TP53 is linked to neoplasm.