TNFSF4 and neoplasm: Jiang et al. (2017) first reported Delta-24-RGDOX, an OAd-expressing OX40L, induced immunogenic cell death and superior tumor-specific activation of lymphocytes in syngeneic glioma mouse models. Since then, the virus was tested in immunocompetent mice with disseminated melanomas (Jiang et al., 2019). Localized treatment with Delta-24-RGDOX mediated tumor-specific T-cell expansion and migration, resulting in efficacious immune activation which is sufficient to elicit an abscopal antimelanoma effect, even in the brain (Jiang et al., 2019).