Because HIF–1α stability and its upregulation is a hallmark of multiple cancers, including endometrial cancer (Chen et al., 2020), it is reasonable to consider that P. somerae may be a contributor to this phenomenon by invading cells and generating an excess of succinate in the host cell akin to the effects of a mitochondrial mutation in succinate dehydrogenase or fumarate reductase genes. This evidence concerns the gene HIF1A and cancer.