AKT1 and polycystic ovary syndrome: Activation of the Akt/mTOR pathway using Akt stimulators in combination with inhibition of Hippo through ovarian fragmentation appears to increase the number of mature follicles in mouse models, but also in patients with POI or PCOS, adjusting follicular growth and ovulation, thereby leading to successful fertilization and pregnancy (49, 52, 84, 85).