SIRT1 and familial dilated cardiomyopathy: Previous researches have reported that BAK (a bioactive monoterpene phenol) and Allisartan isoproxil (a new nonpeptide angiotensin II receptor blocker [ARB] precursor drug) play crucial role in DCM by attenuating myocardial oxidative damage via activating the SIRT1/NRF 2 signaling pathway (91, 123).