For locally advanced inoperable or metastatic patients, depending on some essential clinic-pathologic features of each case (primary tumor localization, expression of somatostatin receptors on cell surface, ki67 value, presence of symptoms and tumor burden), the therapeutic armamentarium includes a great variety of active treatments as SSA (Octreotide or Lanreotide), targeted agents (i.e. the mTOR inhibitor EVE and the anti-angiogenetic drug SUN), peptide receptor radionuclide therapy (PRRT) or chemotherapy (82). Here, MKI67 is linked to neoplasm.