ITGB1 and neoplasm: Additionally, tumor-associated neutrophils (TANs) have been demonstrated to promote tumor progression acting as pro-angiogenic agents (27), by a high expression of different pro-angiogenic factors as vascular endothelial growth factor (VEGF), Interleukin 1 beta (IL-1β) and Integrin Subunit Beta 1 (ITGB1) (28).