Experimentally, NMOSD-ON has been mimicked in vivo by transfer of human AQP4-IgG to animals with pre-established experimental autoimmune encephalomyelitis (EAE) (27) or by direct intracerebral injection near the optic chiasma together with human C via continuous infusion using an implanted mini-pump (11). Here, AQP4 is linked to experimental autoimmune encephalomyelitis.