ALDH2 and head and neck cancer: For the GUCY1A3 gene, among the two identified SNPs in our results, rs13139571 has been described as being associated with elevated blood pressure (43) and we could not identify any previous literature on rs7658967. For ALDH2 rs2238151, the CC genotype is protective against a high level of alcohol consumption and alcohol dependence (44); however, it is also a risk factor for head and neck cancers among heavy drinkers (45).