On the other hand, according to the results of Table 3, the sixth and ninth publications show the effects and underlying mechanisms of insulin and deprssion on PCOS, a complex endocrine and metabolic disorder common to women of childbearing age, characterized by chronic anovulation (disorder or loss of ovulation), and hyperandrogenemia (excessive production of male hormones in women). The gene discussed is INS; the disease is polycystic ovary syndrome.