Flavonoids (fisetin, apigenin, quercitin, chrysin, isoliquiritigenin, rutin, genistein, and others) have anti-inflammatory, antioxidant, and anti-apoptotic properties. These biocompounds can cause inhibition of NF-κB, mostly by reducing phosphorylation of proteins, and thus can improve vascularization in diabetics and reduce the risk of hypertension, which has already been observed in different tissues of humans and animals. Here, NFKB1 is linked to hypertensive disorder.