As a hub protein, HSP90AA1 was differentially expressed in the lung tissues of patients with PAH and indulged in the inflammatory responses of the airway and the smooth muscle function of the bronchia, which reflected that HSP90AA1 may be a potential prognostic biomarker and drug target for the treatment of PAH (Deng et al., 2021). The gene discussed is HSP90AA1; the disease is pulmonary arterial hypertension.