Using immune cells from healthy donors exposed to IFN-α and plasma from patients with severe COVID-19, Combes et al. individually blocked CD64, CD16, and CD32 Fc receptors and found that CD32 blockade enabled the expression of IFN-regulated genes (Combes et al., 2021; Gentili and Hacohen, 2021). This evidence concerns the gene FCGR2A and COVID-19.