Blunted dysferlin expression results in limb-girdle muscular dystrophy type 2B (LGMD2B) and Miyoshi myopathy, which leads to progressive muscle weakness in humans and rodents, and highlights an important role of dysferlin in skeletal muscle homeostasis (Harris et al., 2016; Straub et al., 2018). The gene discussed is DYSF; the disease is Miyoshi myopathy.