L. casei ↓ hind paw volume; ↓ arthritis score; ↓ IFN-γ; ↓ TNF; ↓ IL-1β; ↓ IL-17; ↓ IL-6; rebalance of the lactobacillus species; maintains the redox balance of oxidative stress. This evidence concerns the gene IL6 and arthritic joint disease.