TNF and asthma: Isoliguiritigenin is a member of the flavonoids, which evokes obvious tracheal relaxation effects Liu et al. (2008), and the traditional use of licorice for asthma treating is due to anti-inflammation (Kuang et al., 2018; Huang et al., 2019; Upadhyay et al., 2020) related to inhibiting inflammatory cells’ infiltration, decreasing oxidative stress, and reducing pro-inflammatory mediators’ production, such as TNF-α and IL-1β (Yu et al., 2018; Hou et al., 2019).