CASP3 and malignant colon neoplasm: Besides, studies on multiple human colon cancer cell lines indicated that DAPs induced apoptosis by activating caspase-3 activity (Subramaniam et al., 2008; Selvendiran et al., 2010; Liang et al., 2017; Min et al., 2020) and reducing Bcl-2 protein (Lin et al., 2011; He et al., 2016).