Curcumin delays an early onset of PCa and inhibits the disease progression by modulating multiple key signalling pathways, including AR, AP-1, PI3K/Akt/mTOR, Wnt/ß-catenin, and several molecular targets such as NF-kB, Bcl-2 and cyclin D1 (Wahab et al., 2020). This evidence concerns the gene AKT1 and posterior cortical atrophy.