CCNB1 and posterior cortical atrophy: Curcumin has shown to downregulate CCNB1 expression in PCa (Thangapazham et al., 2008), colon (SU et al., 2006) and lung cancer (Yang et al., 2012; Zhang et al., 2019) which has been linked to G2/M arrest (Yan et al., 2004).