The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway can be activated by external stimuli to phosphorylate the downstream signaling molecule AKT, then phosphorylate the downstream signaling molecule mechanistic target of rapamycin (mTOR), thereby regulating a wide variety of biological responses, including inflammation, cellular proliferation, autophagy, and apoptosis, all of which may be involved in cardiac disease (Wang et al., 2019). This evidence concerns the gene MTOR and heart disorder.