The findings indicated that reynoutrin inhibited MMP2 and MMP9 expressions, as well as NF-κB transcription activity by targeting S100A1, thereby alleviating myocardial inflammation and oxidative stress, reducing infarct size and cardiomyocytes apoptosis, reducing myocardial fibrosis, and show improvements in heart failure caused by ischemia. This evidence concerns the gene S100A1 and heart failure.